In urine, O-dealkyl and N-deethyl-O-dealkyl metabolites and glucuronides were being predominant. Isotonitazene and metonitazene O-dealkyl metabolites were the same molecules and also are most likely developed with the metabolization of structural analogues such as etonitazene, protonitazene, or butonitazene, whose only big difference from isotonita